Mob Psycho 100 (Japanese: モブサイコ100, Hepburn: Mobu Saiko Hyaku) is a Japanese web manga series written and illustrated by One. It was serialized on Shogakukan's Ura Sunday website from April 2012 to December 2017. It has been also available online on Shogakukan's mobile app MangaONE since December 2014. Shogakukan compiled its chapters into sixteen tankōbon volumes. The story follows Shigeo Kageyama, nicknamed Mob, a boy who has strong psychic powers, and his struggles to find the simple happiness he is looking for.

An anime television series adaptation was produced by Bones. The first season aired between July and September 2016, followed by a second season from January to April 2019, and a third season from October to December 2022. A live-action series adaptation aired from January to April 2018. A spin-off manga series, titled Reigen, was serialized in Shogakukan MangaONE app in 2018. In North America, Dark Horse Comics licensed the manga for English publication in 2018. Meanwhile, Crunchyroll licensed the anime series for streaming, with an English dub produced by Bang Zoom! Entertainment in December 2016, and broadcast on Adult Swim's Toonami block in October 2018.

As of July 2016, the manga had over 1.2 million copies in circulation. In 2017, Mob Psycho 100 won the 62nd Shogakukan Manga Award in the shōnen category. The anime adaptation has been considered one of the best anime series of the 2010s.