If the developer of Sweet Crossing: Snake.io release a PC client, you can definitely play it on PC without using an Android emulator. However, you can have a better gaming experience if you play Sweet Crossing: Snake.io on PC with LDPlayer.
With LDPlayer, you can both play Sweet Crossing: Snake.io on your big screen monitor with better graphics, and enhance your gaming experience.
If you need to operate some accurate clicks or combos in Sweet Crossing: Snake.io, you can write macros to trigger combos with one key using the macro feature in keyboard mapping panel. Very creative and time-saving!